About Mr. Gentile
I have had 25 years of experience in organic synthesis. My experience is mainly in Medicinal Chemistry, where my work has been in the preparation and isolation of new drug entities, along with scale-up work. For compound purity we had the use of HPLC and GC instrumentation. This equipment was also used in monitor rates of reaction.
In my free time I enjoy traveling abroad and cruising around Rochester my orange Mustang. My wife and I live in Scottsville, NY along with our 2 children
Related Work History
Technical Writer, Celltech, Rochester, NY
Research Scientist II, Astra Arcus USA, Rochester, NY
Senior Research Associate, Fisions, Rochester, NY
Research Associate, Pennwalt, Rochester, NY
Research Assistant, Pennwalt, Rochester, NY
Senior Technician, Pennwalt, Rochester, NY
Amidine Derivatives with Nitric Oxide Synthetase Activities. Granted on September 15, 1998. Patent No.: 5807885
Zhang ZG, Reif D, Macdonald J, Tan WX, Kamp DK, Gentile RJ, Shakespeare WC, Murray RJ, Chopp M. ARL 17447, a potent and selective neuronal NOS inhibitor decreased infarct volume after transient middle cerebral artery occlusion in rats. Journal of Cerebral Blood Flow & Metabolism. 16(4): 599-604, 1996.
Palmer GC, Stagnitto ML, Ordy JM, Griffith RC, Napier JJ, Gentile RJ, Woodhead JH, White HS, Swinyard EA. Preclinical profile of stereoisomers of the anticonvulsant remacemide in mice. Epilepsy Research, 8(1): 36-48, 1991 Jan-Feb.
Stagnitto ML, Palmer GC, Ordy JM, Griffith RC, Napier JJ, Becker CN, Gentile RJ, Garsek GE, Frankenheim JM, Woodhead JH. Preclinical profile of remacemide: A novel anticonvulsant effective against maximal electroshock seizures in mice. Epilepsy Research, 7(1): 11-28, 1990 Sep-Oct.
Griffith RC, Gentile RJ, Robichaurd RC, Frankenheim JM. Cis-1,3,4,6,7,11b-Hexahydro-2-methyl-7-phynyl-2H,2H+-pyrazino[2,1-a]-isoquinolinium Hydrogen RR- (+)-Tartrate Methanol Solvate. Acta Crystallographica C40, 1103-1105 (1984)
Griffith RC, Gentile RJ, Davidson TA, Scott FL. Convenient one-step synthesis of N-substituted –Methylphenethylamines via Aminomercurtion-Demercuration. Journal of Organic Chemistry. 44,3580 (1979)
Gentile RJ, Macdonald JE, Wallace A, Catalano J, McCreedy S, Kamp DK, Saltzman E, Reif D. The synthesis of bisamidines as brain selective nitric oxide synthase antagonists. 34th National Organic Symposium. April 1995.