Peter Lacelle, Ph.D.
Professor of Biology
location: 306 - Smith Science Center
phone: (585) 594.6123
fax: (585) 594.6482
email: LaCelle_Peter@Roberts.edu

Education

Ph.D., Physiology & Cell Biology, Albany Medical College, Albany, NY, 1992

M.S., Physiology & Cell Biology, Albany Medical College, Albany, NY, 1990

B.A., Chemistry; Houghton College, Houghton, NY, 1984 

Bio

Professional Affiliations

NIH NIAMS Grant K01 AR02097 Department of Dermatology, University of Rochester School of Medicine, 1999-2004

American Society for Cell Biology member, 2000-present

Cancer Center Member, University of Rochester School of Medicine, 1998-Present

NIH NIAMS Grant RO3 AR45066 Department of Dermatology, University of Rochester School of Medicine, 1997-2001

Society for Investigative Dermatology member, 1996-present

NIH Postdoctoral Fellowship, Department of Dermatology, University of Rochester School of Medicine, 1996-1997

Dermatology Foundation Research Fellowship, Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 1994-1996

Associate Member of Sigma Xi, The Scientific Research Society, SUNY at Albany Chapter, 1990

Research Interests

Regulation of growth and differentiation of epidermal keratinocytes (skin cells)

Publications

Manuscripts

LaCelle, P, Blumenstock, FA, McKinley, C, Saba, TM, Vincent, PA, and Gray V. Blood-borne collagenous debris complexes with plasma fibronectin after thermal injury. Blood 75:475-478. 1990.

LaCelle, P, Blumenstock, FA, and Saba, TM. Blood-borne fragments of fibronectin after thermal injury. Blood 77:2037-2041. 1991.

Blumenstock, FA, LaCelle, P, Hermannsdoerfer, A, Giunta, C, Minnear, FL, Cho, E, and Saba, TM. Hepatic removal of 125I-DLT gelatin after burn injury: a model of soluble collagenous debris that interacts with plasma fibronectin. J Leukoc Biol 54(1):56-64. 1993.

Robinson, NA, LaCelle, PT, and Eckert, RL. Involucrin is a covalently crosslinked constituent of highly purified epidermal corneocytes: evidence for a common pattern of involucrin crosslinking in vivo and in vitro. J Invest Dermatol 107:101-107, 1996.

Efimova, T., LaCelle, P., Welter, J.F., Eckert, R.L. Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway. J Biol Chem 273(38):24387-24395,1998.

LaCelle, PT, Lambert A, Ekambaram MC, Robinson NA, and Eckert, RL. In vitro cross-linking of recombinant human involucrin. Skin Pharmacol Appl Physiol 11(4-5):214-226, 1998.

Polakowska, RR, Graf, BA, Falciano, V, LaCelle, P. Tanscription regulatory elements of the first Intron 1 control human transglutaminase type 1 gene expression in epidermal keratinocytes. J Cell Biochem 73(3):355-369, 1999.

LaCelle, PT, and Polakowska, R. Human Homeobox HOXA7 Regulates Keratinocyte Transglutaminase Type 1 and inhibits differentiation. J Biol Chem 276(35):32844-32853, 2001.

Tripp, CS, Blomme, EAG, Chinn, KS, Hardy, MM, LaCelle, P, and Pentland, AP. Epidermal COX-2 Induction Following UV Irradiation; Suggested Mechanism for the Role of COX-2 Inhibition in Photoprotection. J Invest Dermatol 121(4):853-861, 2003.

LaCelle, PT, Agnello, RW, Miller, CC. Hypoxia-inducible factor-1 mediates ultraviolet B-induced keratinocyte vascular endothelial growth factor expression and antagonizes p53. J Biol Chem, Submitted, 2005.

Abstracts

LaCelle, P, Blumenstock, FA, and Saba, TM. Interaction of plasma fibronectin and circulating collagenous tissue debris after burn. FASEB J 4:A849, 1990.

LaCelle, P, Blumenstock, FA, Loegering, DJ, and Saba, TM. Evaluation of fibronectin-dependent denatured collagen clearance from plasma using a non-metabolizable tracer. FASEB J 5:A1631, 1991.

Homeobox HOXA7 regulation of epidermal transglutaminase. J Invest Dermatol 110(4):604, 1998.

A Biologically Active Retinoic Acid Response Element (RARE) Controls Human Transglutaminase Type 1 Gene Promoter Activity in Epidermal Keratinocytes. J Invest Dermatol 112(4):674, 1999.

Human Homeobox HOXA7 Regulates Keratinocyte Transglutaminase Type 1 and Inhibits Differentiation. J Invest Dermatol 116(4), 2001.

Epidermal Prostanoid Receptor EP1 expression and regulation of keratinocyte differentiation. J Invest Dermatol, 119(1):275, 2002.

Homeobox Factors HOXA7 and HOXA5 Exhibit Differential Regulation of Keratinocyte Growth, Differentiation, and Apoptosis. J Invest Dermatol 121(1):A771, 2003.

Mechanisms of HOXA7 and HOXA5 Regulation of Keratinocyte Apoptosis. J Invest Dermatol 122(3):A100, 2004.

Hypoxia-inducible factor-1α mediates ultraviolet B-induced keratinocyte vascular endothelial growth factor expression and antagonizes p53. J Invest Dermatol (in press) 2005.